CSC8324 : Modelling Cellular Systems
- Offered for Year: 2024/25
- Module Leader(s): Dr Harold Fellermann
- Owning School: Computing
- Teaching Location: Newcastle City Campus
Semesters
Your programme is made up of credits, the total differs on programme to programme.
| Semester 1 Credit Value: | 10 |
| ECTS Credits: | 5.0 |
| European Credit Transfer System | |
Aims
To understand how biological systems can be represented at different levels of abstraction.
To introduce a range of computational modelling approaches and to select an appropriate modelling strategy for a given biological domain and problem.
To understand how models may be used to represent cellular machinery at a systems level and how models can be used to generate biological hypotheses.
Outline Of Syllabus
- Introduction to modelling biochemical systems.
- Abstraction and levels of abstraction in modelling.
- Structural models: ER modelling and network models.
- Metabolic modelling using flux balance analysis.
- Dynamic modelling using continuous differential equations.
- Simulation.
- Modelling discrete stochastic systems.
- Parameter estimation and inference.
- Biological hypothesis generation.
- Model optimisation.
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Structured Guided Learning | Lecture materials | 16 | 0:45 | 12:00 | Revise lecture material. |
| Scheduled Learning And Teaching Activities | Lecture | 16 | 1:00 | 16:00 | Lectures online or pre-recorded |
| Guided Independent Study | Assessment preparation and completion | 1 | 4:00 | 4:00 | Formative assessment coursework. |
| Guided Independent Study | Assessment preparation and completion | 7 | 2:00 | 14:00 | Coursework for summative assignment. |
| Scheduled Learning And Teaching Activities | Drop-in/surgery | 4 | 1:00 | 4:00 | Drop-in tutorials (weeks 1-4) |
| Guided Independent Study | Independent study | 45 | 1:00 | 45:00 | Background reading. |
| Scheduled Learning And Teaching Activities | Scheduled on-line contact time | 5 | 1:00 | 5:00 | Online tutorials |
| Total | 100:00 |
Teaching Rationale And Relationship
Lectures and online lecture materials will be used to introduce the learning materials and for demonstrating the key concepts by example. Students are expected to follow-up lectures by re-reading and annotating lecture notes to aid deep learning.
Tutorials will be used to provide opportunities to clarify lecture material.
Practicals will be used to emphasise the learning material and its application to the solution of problems and exercises set as coursework, during which students will analyse problems as individuals.
This is a very practical subject, and it is important that the learning materials are supported by hands-on opportunities provided by practical classes. Students are expected to spend time on coursework outside timetabled practical classes.
Students aiming for 1st class marks are expected to widen their knowledge beyond the content of lecture notes through background reading.
Assessment Methods
The format of resits will be determined by the Board of Examiners
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Practical/lab report | 1 | M | 100 | Summative Assessment: A practical report on a more advanced modelling exercise. Max 2,000 words. |
Formative Assessments
Formative Assessment is an assessment which develops your skills in being assessed, allows for you to receive feedback, and prepares you for being assessed. However, it does not count to your final mark.
| Description | Semester | When Set | Comment |
|---|---|---|---|
| Practical/lab report | 1 | M | Compulsory formative assessment: A preliminary report on the model for a modelling exercise. Max 750 words |
Assessment Rationale And Relationship
The coursework will assess the students’ ability to understand and apply the concepts of a range of a biological modelling theories and techniques to a given biological system. The first coursework component is a compulsory formative assessment which will assess the students growing knowledge of the field and provide feedback. The second component is a summative assessment testing the students’ ability to apply the theory they have learnt at the end of the module.
Reading Lists
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- CSC8324's Timetable